Fixed Combinations of Eucalyptus oil, Primrose root, and Thyme

Published July 14, 1993.Published April 4, 1992.
List of German Commission E Monographs (Phytotherapy)

Composition of Drug

Fixed combinations consisting of:

Eucalyptus oil corresponding to B. Anz. 177a, September 24, 1986;
Primrose root corresponding to B. Anz. 122, July 6, 1988;
Thyme corresponding to B. Anz. 228, December 5, 1984;

and their preparations in effective dosage.


Colds and diseases of the upper respiratory tract with viscous phlegm.


Inflammatory diseases of the gastrointestinal and biliary regions; severe liver diseases.

Side Effects

Occasionally, gastric discomfort, nausea, vomiting and diarrhea may occur.

Interactions with Other Drugs

Eucalyptus oil induces the enzyme system responsible for the breakdown of foreign substances in the liver. The effectiveness of other medications may, therefore, be diminished and/or shortened.


Unless otherwise prescribed:

The individual components of the combination must each be present at 30 - 50 percent of the daily dosage given in the monographs for the individual herbs.

Mode of Administration

Comminuted drug and galenical preparations for oral intake.


An expectorant effect is documented for preparations of primrose root, thyme, and eucalyptus oil. In addition, eucalyptus oil and primrose root have secretolytic action. Eucalyptus oil and thyme have a mild spasmolytic action, and thyme, an antibacterial action. Pharmacological tests for the effectiveness of fixed combinations are not available.