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Fixed Combinations of Anise seed, Marshmallow root, Primrose root, and Sundew

Published April 4, 1992.
List of German Commission E Monographs (Phytotherapy)

Composition of Drug

Fixed combinations consisting of:

Anise seed corresponding to B. Anz. 122, July 6, 1988;
Marshmallow root corresponding to B. Anz. 43, March 2, 1989;
Primrose root corresponding to B. Anz. 122, July 6, 1988;
Sundew corresponding to B. Anz. 228, December 5, 1984;

and their preparations in effective dosage.


Catarrhs of the upper respiratory tract with spastic, dry cough.


Allergy to anise and anethole.

Side Effects

Occasionally allergic reactions of the skin, respiratory tract, and gastrointestinal tract. Individual cases of gastric disorders and nausea may occur.

Interactions with Other Drugs

None known.

Warning: The absorption of other, simultaneously taken medications may be delayed.


Unless otherwise prescribed:

Marshmallow and sundew herb must be at the concentration given in the monographs. The other components of the combination must be each equivalent to 50 - 75 percent of the daily dosage given in the monographs for the individual herbs.

Mode of Administration

Comminuted drug and galenical preparations for oral intake.


For preparations of primrose root and anise an expectorant action is documented. Anise and sundew have, in addition, a spasmolytic effect. Primrose root is secretolytic, anise is antibacterial and sundew is antitussive. Marshmallow has a soothing effect and inhibits in-vitro mucociliary activity. Pharmacological tests for the effectiveness of fixed combinations are not available.