Fixed Combinations of Angelica root, Gentian root, and Caraway seed

Published March 11, 1992.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of angelica root, gentian root, and caraway seed.

Composition of Drug

Fixed combinations consisting of:

Angelica root with herb corresponding to the monograph published March 16, 1990;
Gentian root corresponding to the monograph published November 11, 1985;
Caraway seed corresponding to the monograph published December 14, 1989;

as well as their preparations in effective dosage.


Loss of appetite, peptic discomfort, such as sensation of fullness and flatulence, mild, spastic discomfort in the gastrointestinal area.


Gastric and duodenal ulcers.

Side Effects

Particularly predisposed individuals may occasionally experience headaches.

Furanocoumarin, contained in angelica root, renders the skin photosensitive and in combination with ultraviolet light can cause inflammation of the skin. Prolonged sun bathing and exposure to UV light, therefore, should be avoided during the course of therapy with angelica root.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

Caraway must be present in the dosage given in its monograph.

Angelica root and gentian root must be at the concentration of 50 - 75 percent of the daily dosage given in the individual monographs.

Deviating dosages must be justified specifically for the preparation (e.g., comparison of bitter values).

Mode of Administration

Comminuted drug for tea and other bitter-tasting galenical preparations for oral use.


A carminative action is documented for angelica root, gentian root, and caraway seed. Pharmacological experiments for the fixed combinations are not available.