Fixed Combinations of Peppermint leaf, Caraway seed, Chamomile flower, and Bitter Orange peel

Published December 18, 1991.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of peppermint leaf, caraway seed, chamomile flower, and bitter orange peel.

Composition of Drug

Fixed combinations consisting of:

Peppermint leaf corresponding to November 11, 1985 (B. Anz. p. 14335);
Caraway seed corresponding to December 14, 1989 (B. Anz. 22a, February 1, 1990);
Chamomile flower corresponding to November 1, 1984 (B. Anz. p. 13327);
Bitter orange peel corresponding to October 15, 1987 (B. Anz. 193);

and their preparations in effective dosage.


Loss of appetite; dyspeptic discomfort, such as sensation of fullness and flatulence.


In case of gallbladder disease, only to be used after consultation with a physician or pharmacist.

Side Effects

Furanocoumarins contained in this preparation render the skin light sensitive, which, in connection with exposure to UV light may cause inflammation of the skin. For the duration of administration of bitter orange peel or preparations thereof, extended exposure to sun and UV light should be avoided.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

The individual components of the combination must be equivalent to 25 - 40 percent of the daily dosage given in the monographs for the individual herbs.

Mode of Administration

Comminuted drug for teas and other galenical preparations for oral use.


A spasmolytic effect is documented for preparations of peppermint leaf, caraway seed, and chamomile flower; a carminative effect for peppermint leaf and bitter orange peel. Pharmacological tests for the effectiveness of fixed combinations are not available.