Fixed Combinations of Milk Thistle fruit, Peppermint leaf, and Wormwood

Published December 18, 1991.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of milk thistle fruit, peppermint leaf, and wormwood.

Composition of Drug

Fixed combinations consisting of:

Milk Thistle fruit corresponding to B. Anz. 50, March 13, 1986;
Peppermint leaf corresponding to B. Anz. 223, November 30, 1985;
Wormwood corresponding to B. Anz. 228, December 5, 1984;

and their preparations in effective dosage.


Dyspeptic discomfort, especially functional disorders of the biliary tract.


In case of gallstones, to be taken only after consultation with a physician or pharmacist.

Side Effects

None known.

Interaction with Other Drugs

None known.


Unless otherwise prescribed:

The components of the combination must each be present at 30 - 50 percent of the daily dosage given in the monographs for the individual herbs.

Deviating dosages must be justified for the specific preparation (e.g., comparative bitter values).

Mode of Administration

Comminuted drug and galenical preparations thereof for oral use.


A choleretic and carminative effect is documented for preparations of milk thistle fruit, peppermint leaf, and wormwood. Peppermint leaf also has a spasmolytic action. Pharmacological tests for the effectiveness of fixed combinations are not available.