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Fixed Combinations of Dandelion root with herb, Peppermint leaf, and Artichoke leaf

Published December 18, 1991.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of dandelion root with herb, peppermint leaf, and artichoke leaf.

Composition of Drug

Fixed combinations consisting of:

Dandelion root with leaf corresponding to B. Anz. 228, December 5, 1984;
Peppermint leaf corresponding to B. Anz. 223, November 30, 1985;
Artichoke leaf corresponding to B. Anz. 122, July 6, 1988;

and their preparations in effective dosage.


Spastic epigastric discomfort due to functional disorders of the biliary system.


Obstruction of the biliary tract, empyema of gallbladder, ileus. Known allergies to artichoke and other composites. In case of gallbladder disease, to be used only after consultation with a physician or pharmacist.

Side Effects

None known.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

Peppermint leaves must be present in the amount given in the monograph. The other two components of the combination must be each equivalent to 50 - 75 percent of the daily dosage indicated in the monographs for the individual herbs.

Deviating dosages must be justified for the specific preparation (e.g., comparison of bitter values).

Mode of Administration

Comminuted drug and galenical preparations for oral intake.


A cholagogic effect has been documented for dandelion root with herb and artichoke leaf. Peppermint leaf has a direct spasmolytic effect on the smooth muscles of the gastrointestinal tract. Pharmacological tests for the effectiveness of fixed combinations are not available.