Fixed Combinations of Angelica root, Gentian root, and Fennel

Published December 18, 1991.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of angelica root, gentian root, and fennel.

Composition of Drug

Fixed combinations consisting of:

Angelica root corresponding to B. Anz. 101, June 1, 1990;
Gentian root corresponding to B. Anz. 223, November 30, 1985;
Fennel corresponding to B. Anz. 74, April 19, 1991;

and their preparations in effective dosage.


Loss of appetite; dyspeptic disorders, such as sensation of fullness and flatulence; mild, spastic disturbances of the gastrointestinal tract.


Gastric and duodenal ulcers.


Preparations other than teas and preparations with essential oil contents comparable to those of teas. Side Effects In individual cases, allergic reactions of the skin and respiratory tract. Occasionally, headaches.

Warning: Furanocoumarin contained in this preparation causes light-sensitivity of the skin and may lead to inflammation of the skin in combination with UV exposure. During use of this preparation, extended sun bathing and intensive UV radiation should be avoided.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

Fennel must be present in the dosage recommended in the monograph. Angelica root and gentian root must be present at a concentration of 50 - 75 percent of the daily dosage recommended in the monographs for the individual herbs. Deviating dosages must be documented for the specific preparation (e.g., through comparison of bitter values).

Mode of Administration

Bitter-tasting galenical preparations for oral intake.

Duration of Use

Fennel preparations should not be used over extended periods of time (several weeks) without medical advice.


An appetite-stimulating action with increased gastric secretion has been documented for preparations of angelica root and gentian root. Fennel has a spasmolytic action. Pharmacological tests for the effectiveness of fixed combinations are not available.