Fixed Combinations of Angelica root, Gentian root, and Bitter Orange peel

Published December 18, 1991.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of angelica root, gentian root, and bitter orange peel.

Composition of Drug

Fixed combinations consisting of:

Angelica root corresponding to B. Anz. 101, June 1, 1990;
Gentian root corresponding to B. Anz. 223, November 30, 1985;
Bitter Orange peel corresponding to B. Anz. 193, October 15, 1987;

and their preparations in effective dosage.


Loss of appetite; dyspeptic disorders, such as sensation of fullness and flatulence.


Gastric and duodenal ulcers.

Side Effects

Furanocoumarin contained in this preparation causes light-sensitivity of the skin and may lead to inflammation of the skin in combination with UV exposure. During use of angelica root, gentian root and bitter orange peel, or preparations thereof, extended sun bathing, and intensive UV radiation should be avoided.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

The individual components of the combination must be present in amounts corresponding to 30 - 50 percent of the daily dosage indicated in the monographs for the individual herbs. Deviating dosages must be documented for the specific preparation (e.g., through comparison of bitter values).

Mode of Administration

Comminuted herbs and other bitter tasting preparations for oral use.


An appetite-stimulating action with increased gastric secretion has been documented for preparations of angelica root, gentian root and bitter orange peel. Pharmacological tests for the effectiveness of fixed combinations are not available.