Cola nut (Colae semen)

Published July 12, 1991.
List of German Commission E Monographs (Phytotherapy)


Name of Drug

Colae semen, cola nut.

Composition of Drug

Cola nut consists of the endosperm freed from the testa of various Cola species Schott et Endlicher, particularly C. nitida (Ventenat) Schott et Endlicher [Fam. Sterculiaceae], as well as its preparations in effective dosage.

The drug contains at least 1.5 percent methylxanthine (caffeine, theobromine).


Mental and physical fatigue.


Gastric and duodenal ulcers.

Side Effects

Sleep disorders, over-excitability, nervous restlessness, and gastric irritations may occur.

Interactions with Other Drugs

Strengthening of the action of psychoanaleptic drugs and caffeine-containing beverages.


Unless otherwise prescribed:

Daily dosage:

2 - 6 g cola nut (Erg. B. 6); 0.25 - 0.75 g cola extract (Erg. B. 6); 2.5 - 7.5 g cola liquid extract (Erg. B. 6); 10 - 30 g cola tincture (Erg. B. 6); 60 - 180 g cola wine (Erg. B. 6). Mode of Administration Powdered drug and other galenical preparations for internal use.


From animal experiments:

Analeptic Stimulates production of gastric acid Lipolytic Increases motility In humans:

Compared to methylxanthine, caffeine is a weaker diuretic and positively chronotropic.