Uzara root (Uzarae radix)

Published September 1, 1990.
List of German Commission E Monographs (Phytotherapy)


Name of Drug

Uzarae radix, uzara root.

Composition of Drug

Uzara root consists of the dried, underground parts of 2- to 3- year-old plants of Xysmalobium undulatum (L.) R. Brown [Fam. Asclepiadaceae], as well as their preparations in effective dosage.

The drug contains glycosides with cardenolide structure.


Nonspecific, acute diarrhea.


Therapy with cardiac glycosides.

Side Effects

None known.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

Initial single dosage:

preparations equivalent to 1 g herb or 75 mg total glycosides. Daily dosage:

equivalent to 45 - 90 mg of total glycosides, calculated as uzarin. Mode of Administration Ethanol-water extracts in liquid form, or as dry extracts obtained from methanol-water extractions for internal use.

Duration of Administration

If diarrhea persists for more than 3 - 4 days, consult a physician.


Inhibits intestinal motility
In high dosage, digitalis-like effects on the heart.