Fixed Combinations of Licorice root and German Chamomile flower

Published July 14, 1993.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of licorice root and chamomile flower.

Composition of Drug

Fixed combinations consisting of:

Licorice root with herb corresponding to the monograph published May 6, 1985 (B. Anz. p. 4953);
Chamomile flower corresponding to the monograph published November 1, 1984 (B. Anz. p. 13326);

as well as their preparations in effective dosage.

Pharmacological Properties, Pharmacokinetics, Toxicology For preparations of licorice and chamomile, an antispasmodic action is documented. Chamomile has an antiphlogistic and wound healing effect.

Glycyrrhizic acid and the aglycone of glycyrrhizic acid enhance the healing of gastric ulcers, according to controlled, clinical studies. Pharmacological studies pertaining to the fixed combination are not available.

Clinical Data 1. Uses For symptomatic treatment of irritated (nervous) stomach and simple gastric ulcers.

2. Contraindications

For a daily dosage up to 100 mg glycyrrhizin:

None known. For a daily dosage of more than 100 mg of glycyrrhizin:

Cholestatic liver disorders, liver cirrhosis, hypertonia, hypokalemia, severe kidney insufficiency, pregnancy. 3. Side Effects For a daily dosage up to 100 mg glycyrrhizin:

None known. For a daily dosage of more than 100 mg of glycyrrhizin:

Extended use and higher dosages can cause mineralocorticoid effects, such as sodium and water retention, loss of potassium with high blood pressure, edema and hypokalemia with muscle weakness, and, in rare cases, myoglobinuria. 4. Interactions with Other Drugs For a daily dosage up to 100 mg glycyrrhizin:

None known. For a daily dosage of more than 100 mg of glycyrrhizin:

Loss of potassium due to other medications, e.g., thiazide and loop diuretics, can be intensified. Loss of potassium increases the sensitivity to digitalis glycosides. 5. Dosage Unless otherwise prescribed:

The individual combination partners must be present at the concentration of 50 - 75 percent of the daily dosage given in the individual monographs.

6. Mode of Administration

Comminuted herb and preparations for oral use.

7. Duration of Administration

Without medical advice, not longer than 4 - 6 weeks.