Fixed Combinations of Marshmallow root, Primrose root, Licorice root, and Thyme oil

Published April 4, 1992.
List of German Commission E Monographs (Phytotherapy)

Composition of Drug

Fixed combinations of:

Marshmallow root corresponding to B. Anz. 43, March 2, 1989;
Primrose root corresponding to B. Anz. 122, July 6, 1989;
Licorice root corresponding to B. Anz. 90, May 15, 1985;
Thyme oil corresponding to B. Anz. 228, December 5, 1984;

and their preparations in effective dosage.

Uses

Catarrhs of the upper respiratory tract with dry cough.

Contraindications

For a daily dosage up to 100 mg glycyrrhizin:

None known. For a daily dosage of more than 100 mg glycyrrhizin:

Cholestatic liver diseases, liver cirrhosis, hypertonia, hypokalemia, severe kidney insufficiency, pregnancy. Side Effects For a daily dosage up to 100 mg glycyrrhizin:

Isolated cases of gastric discomfort and nausea. For a daily dosage of more than 100 mg glycyrrhizin:

Extended administration and higher dosages may cause mineralocorticoid effects in the form of sodium and water retention, loss of potassium with hypertonia, edema, and hypokalemia with muscular asthenia, and in rare cases, myoglobinuria. Isolated cases of gastric discomfort and nausea. Interactions with Other Drugs For a daily dosage up to 100 mg glycyrrhizin:

None known. Warning: The absorption of other, simultaneously taken drugs can be delayed.

For a daily dosage of more than 100 mg glycyrrhizin:

Loss of potassium through other medications can be increased, e.g., thiazide and loop diuretics. The sensitivity toward digitalis glycosides increases with loss of potassium. Warning: The absorption of other, simultaneously taken medications can be delayed.

Dosage

Unless otherwise prescribed:

Marshmallow root must be present at the concentration given in the monograph. Licorice root, primrose root, and thyme oil must each be present at 30 - 50 percent of the daily dosage given in the monographs for the individual herbs.

Mode of Administration

Liquid and solid forms of administration for oral intake.

Duration of Use

Not longer than 4 - 6 weeks without the advice of a physician.

Actions

An expectorant effect is documented for licorice root, primrose root, and thyme oil; for licorice root and primrose root, also a secretolytic action. In addition, thyme oil has a soothing effect and inhibits mucociliary activity in-vitro. Pharmacological tests for the effectiveness of fixed combinations are not available.