Fixed Combinations of Anise oil, Primrose root, and Thyme

Published April 4, 1992.
List of German Commission E Monographs (Phytotherapy)

Composition of Drug

Fixed combinations consisting of:

Anise oil corresponding to B. Anz. 122, July 6, 1988;
Primrose root corresponding to B. Anz. 122, July 6, 1988;
Thyme herb corresponding to B. Anz. 228, December 5, 1984;

and their preparations in effective dosage.


Colds and diseases of the upper respiratory tract with viscous phlegm.


Oversensitivity to anise and anethole.

Side Effects

Occasionally, allergic reactions of the skin, respiratory tract, and gastrointestinal tract. Individual cases of gastric discomfort and nausea may occur.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

The individual components of the combination must correspond to 30 - 50 percent of the daily dosage given in the monographs for the individual herbs.

Mode of Application

Comminuted drug and galenical preparations for oral intake.


An expectorant effect is documented for anise oil, primrose root, and thyme. In addition, anise oil and thyme have an antibacterial and bronchospasmolytic action. Primrose has a secretolytic action. Pharmacological tests for the effectiveness of fixed combinations are not available.