Fixed Combinations of Angelica root, Gentian root, and Wormwood

Published March 11, 1992.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of angelica root, gentian root, and wormwood.

Composition of Drug

Fixed combinations consisting of:

Angelica root with herb corresponding to the monograph published March 16, 1990;
Gentian root corresponding to the monograph published November 11, 1985;
Wormwood corresponding to the monograph published November 1, 1984;

as well as their preparations in effective dosage.


Loss of appetite, peptic discomfort, such as sensation of fullness and flatulence.


Gastric and duodenal ulcers.

Side Effects

Furanocoumarin, contained in angelica root, renders the skin photosensitive and in combination with ultraviolet light can cause inflammation of the skin. Prolonged sun bathing and exposure to UV light, therefore, should be avoided during the course of therapy with angelica root.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

The single combination components must be at the concentration of 30 - 50 percent of the daily dosage given in the individual monographs. Deviating dosages must be justified specifically for the preparation (e.g., comparison of bitter values).

Mode of Administration

Comminuted drug for tea and other bitter-tasting galenical preparations for oral use.


Appetite-stimulating and gastric juice-secreting actions are documented for preparations of angelica root, gentian root, and wormwood herb. Pharmacological experiments for fixed combinations are not available.