Fixed Combinations of Javanese Turmeric root, Celandine herb, and Wormwood

Published December 18, 1991; Revised September 3,1992.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of Javanese turmeric root, celandine herb, and wormwood.

Composition of Drug

Fixed combinations consisting of:

Javanese turmeric root corresponding to B. Anz. 122, July 6, 1988;
Celandine herb corresponding to B. Anz. 90, May 15, 1985;
Wormwood corresponding to B. Anz. 228, December 5, 1984;

and their preparations in effective dosage.

Uses

Spastic epigastric discomfort due to functional disorders of the biliary tract.

Contraindications

Obstruction of the biliary tract. If suffering from gallstones, to be used only after consultation with a physician or pharmacist.

Side Effects

Gastric discomfort may occur with extended use.

Interactions with Other Drugs

None known.

Dosage

Unless otherwise prescribed:

Celandine herb must be present at the dosage given in the monograph. The other components of the combination must each be present at 30 - 50 percent of the daily dosage given in the monographs for the individual herbs.

Deviating dosages must be justified for the specific preparations (e.g., comparative bitter values).

Mode of Administration

Comminuted drug and galenical preparations thereof for oral intake.

Actions

For preparations of wormwood and Javanese turmeric root, a choleretic effect is documented; for celandine herb a papaverine-like, mildly spasmolytic effect on the gastrointestinal tract is known. Pharmacological tests for the effectiveness of fixed combinations are not available.