Fixed Combinations of Angelica root, Gentian root, Wormwood, and Peppermint oil

Published December 18, 1991.
List of German Commission E Monographs (Phytotherapy)

Name of Drug

Fixed combinations of angelica root, gentian root, wormwood, and peppermint oil.


Fixed combinations consisting of:

Angelica root corresponding to B. Anz. 101, June 1, 1990;
Gentian root corresponding to B. Anz. 223, November 30, 1985;
Wormwood corresponding to B. Anz. 228, December 5,1984;
Peppermint oil corresponding to B. Anz. 50, March 13, 1986;

and their preparations in effective dosage.


Loss of appetite; dyspeptic disorders, such as sensation of fullness and flatulence; mild, spastic discomfort of the gastrointestinal tract.


Gastric and duodenal ulcers. Obstruction of the biliary tract, gallbladder inflammation, severe liver damage. If suffering from gallstones, use only after consultation with a physician or pharmacist.

Side Effects

Sensitive patients may suffer from gastric discomfort. Furanocoumarin contained in this preparation causes light-sensitivity of the skin and may lead to inflammation of the skin in combination with UV exposure. During use of angelica root or preparations thereof, extended sun bathing and intensive UV radiation should be avoided.

Interactions with Other Drugs

None known.


Unless otherwise prescribed:

Peppermint oil must be present at the amount given in the monograph. The other individual components of the combination must be present in amounts corresponding to 30 - 50 percent of the daily dosage indicated in the monographs for the individual herbs.

Deviating dosages must be documented for the specific preparation (e.g., through comparison of bitter values).

Mode of Administration

Comminuted drug, as well as essential oil and other bitter-tasting galenical preparations for oral intake.


An appetite-stimulating action with increased gastric secretion has been documented for preparations of angelica root, gentian root and wormwood. For peppermint leaves and Angelica root, a spasmolytic and carminative effect is known. Pharmacological tests for the effectiveness of fixed combinations are not available.