Published July 12, 1991.
List of German Commission E Monographs (Phytotherapy)
Colae semen, cola nut.
Cola nut consists of the endosperm freed from the testa of various Cola species Schott et Endlicher, particularly C. nitida (Ventenat) Schott et Endlicher [Fam. Sterculiaceae], as well as its preparations in effective dosage.
The drug contains at least 1.5 percent methylxanthine (caffeine, theobromine).
Mental and physical fatigue.
Gastric and duodenal ulcers.
Sleep disorders, over-excitability, nervous restlessness, and gastric irritations may occur.
Strengthening of the action of psychoanaleptic drugs and caffeine-containing beverages.
Unless otherwise prescribed:
2 - 6 g cola nut (Erg. B. 6); 0.25 - 0.75 g cola extract (Erg. B. 6); 2.5 - 7.5 g cola liquid extract (Erg. B. 6); 10 - 30 g cola tincture (Erg. B. 6); 60 - 180 g cola wine (Erg. B. 6). Mode of Administration Powdered drug and other galenical preparations for internal use.
From animal experiments:
Analeptic Stimulates production of gastric acid Lipolytic Increases motility In humans:
Compared to methylxanthine, caffeine is a weaker diuretic and positively chronotropic.