Senecio herb (Senecionis herba)

Published July 27, 1990.
List of German Commission E Monographs (Phytotherapy)

Fuchskreuzkraut

Name of Drug

Senecionis herba, senecio herb.

Composition of Drug

Senecio herb consists of the above-ground parts of Senecio nemorensis ssp. fuchsii C. Gmelin [Fam. Asteraceae], as well as preparations thereof.

Uses

Senecio herb is used for diabetes mellitus, hemorrhage, high blood pressure, for spasms, and as a uterine stimulant.

The effectiveness for diffuse mucosal hemorrhages is not sufficiently verified.

The effectiveness for the other claimed uses is not documented.

Risks

Senecio herb contains varying amounts of toxic pyrrolizidine alkaloids (PA) which are known to have organotoxic, in particular hepatotoxic, effects. Carcinogenic activity, operating through a genotoxic mechanism, has been demonstrated in animal experiments.

In addition to being an ineffective remedy for diabetes mellitus, use of the herb represents a considerable health risk.

Evaluation

The therapeutic administration of senecio herb is not justifiable because of its insufficient or undocumented effectiveness and the presence of toxic pyrrolizidine alkaloids.

Action

Shortening of hemorrhage.