Published November 30, 1985; Revised March 13, 1990.
List of German Commission E Monographs (Phytotherapy)
Gentianae radix, gentian root.
Gentian root consists of the dried, unfermented roots and rhizome of Gentiana lutea L. [Fam. Gentianaceae], containing a bitter value of not less than 10,000, as well as its preparations in effective dosage.
The drug contains bitter principles (amarogentin, gentiopicroside) and the bitter-tasting gentiobiose.
Digestive disorders, such as loss of appetite, fullness, flatulence.
Gastric and duodenal peptic ulcers.
Especially sensitive persons may occasionally experience headaches.
Unless otherwise prescribed:
Tincture (according to Erg. B. 6):
1 - 3 g; Fluidextract (according to Erg. B. 6):
2 - 4 g; Root:
2 - 4 g. Mode of Administration Comminuted drug and dried extracts for infusions, bitter-tasting forms of medications for oral administration.
The essential active principles are the bitter substances contained in the herb. These bring about a reflex excitation of the taste receptors, leading to increased secretion of saliva and the digestive juices. Gentian root is therefore considered to be not simply a pure bitter, but also a roborant and tonic.
In animal experimentation there are indications that bronchial secretion is increased.